Python frameworks are powerful tools for building robust web applications. Explore the top picks for 2023 in this comprehensive guide.
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Python frameworks are essential tools for developers, providing ready-made components and libraries that simplify building web applications, APIs, and more. With frameworks, you can save time by focusing on application logic instead of basic setup, security, and database management. This efficiency and Python’s simplicity make its frameworks especially popular across industries for developing scalable, secure, and maintainable solutions.
I have put together a list of the well-known Python frameworks for you. I believe that this short list gives you enough information to choose the proper Python framework for you next project.
The Popularity Of Python
The popularity of Python among other programming languages is shown by the TIOBE index, which is a trusted indicator of the popularity of programming languages. As you can see, Python is increasing rapidly.

What are Python Frameworks?
Python frameworks are sets of pre-written code that provide a base for tailored development. They automate routine tasks, making your coding process smoother and more efficient. By using a Python framework, you can concentrate on your project's unique features, reducing redundancy.
Python Web Frameworks
Python web framework | Main features | Typical use cases |
---|---|---|
Full-featured, scalable, includes ORM, auth, and more | Full-stack web development, large applications | |
Lightweight, extensible, no built-in database abstraction | Small to medium web applications | |
Flexible and scalable, suitable for both small and large applications | Large-scale web applications that require extensibility and fine-grained control | |
Full-stack framework, includes a web-based IDE and is designed to guide a web developer to follow good software engineering practices | Rapid development of secure database-driven web applications |
Django
Three specific use cases where Django truly shines:
E-commerce Platforms: Django's pre-built modules for handling user authentication, session management, and payment processing streamline the development of secure and scalable online shops.
Content Management Systems (CMS): With its robust administrative interface and dynamic database access layer, Django facilitates the swift creation of systems that can manage vast amounts of content and user interactions efficiently.
Data-Driven Websites: Leveraging Django’s ORM system allows for intuitive management and querying of databases, making it ideal for websites that require complex data interactions and real-time data updates.

Flask
Three distinct use cases where Flask excels:
Prototyping and Small Web Applications: The simplicity of Flask facilitates rapid development and iteration, which is perfect for prototyping ideas or building small-scale web applications that do not require a full-stack framework's complexity.
Microservices: Flask's lightweight and modular design makes it ideal for building microservices where each service can be developed independently with its own stack of extensions and libraries.
API Development: For developers aiming to build a clean, RESTful API quickly, Flask provides the bare essentials, allowing for precise control over request handling and response mechanisms without imposing too much structure.

Pyramid
Here are three compelling use cases where Pyramid shows its strengths:
Large-scale web applications: Pyramid's flexibility and scalability make it ideal for developing large-scale web applications, allowing developers to start simple and expand to a full-featured application without re-implementing the core.
API-heavy applications: With features like traversal and URL dispatch, Pyramid excels in projects that require sophisticated URL routing and RESTful request handling, making it suitable for backend systems with extensive API needs.
Complex database-driven applications: Pyramid seamlessly integrates with multiple databases and supports complex transactions, catering well to applications with intricate database interactions and heavy data processing needs.

Web2py
Three use cases that demonstrate Web2py's effectiveness:
Rapid Development of Data-driven Web Applications: Web2py comes with a built-in web-based IDE and database abstraction layer that simplifies creating dynamic, data-driven web applications. This feature accelerates development by providing automatic forms and interfaces from database definitions.
Educational Tools and Prototyping: Its ease of use and comprehensive documentation make Web2py particularly appealing for educational purposes and prototyping, where students and developers can quickly build and test web applications without getting bogged down in configuration details.
Enterprise Solutions: With robust security features such as form validation, session management, and role-based access control, Web2py is suitable for enterprise applications that demand high security and scalability while maintaining development simplicity.

Python API Frameworks
Python API framework | Main features | Typical use cases |
---|---|---|
Full-featured toolkit; Serialization, authentication, and viewsets | Building robust Web APIs for mobile and web applications | |
Modern, fast web framework for building APIs with Python 3.7+ based on standard Python type hints. | Building high-performance asynchronous APIs, especially suitable for microservices | |
Extension for Flask that adds support for quickly building REST APIs. It is lightweight and easy to use. | Small to medium applications requiring a clean and simple RESTful API |
Django REST Framework
Here are three specific use cases where DRF is highly effective:
Full-Featured Web APIs: DRF comes with extensive features like serialization, authentication, and permissions, making it an ideal choice for building robust, full-featured APIs that can handle everything from CRUD operations to complex user interactions.
Rapid Prototyping for Data-Driven Applications: With its modular components and Django’s built-in ORM, DRF allows developers to rapidly create and iterate APIs for data-driven applications, enabling quick prototyping and testing of ideas with real data.
APIs with Advanced Permissions and Authentication: DRF’s support for complex permission structures and multiple authentication methods (such as JWT, OAuth) makes it well-suited for building secure APIs where data access needs to be carefully managed across different user roles and levels.

FastAPI
Here are three use cases where FastAPI shines:
High-Performance Asynchronous APIs: FastAPI is built on ASGI (Asynchronous Server Gateway Interface), making it an ideal choice for applications requiring high concurrency, such as real-time data applications or IoT systems with heavy API requests.
Data Validation and Processing: With built-in support for Pydantic, FastAPI automatically validates and serializes data based on type hints, making it excellent for building data-intensive applications where validation and data integrity are critical.
Microservices and Serverless Architectures: FastAPI’s lightweight nature and speed make it well-suited for microservices and serverless applications, allowing developers to deploy fast, isolated services that scale well across cloud environments.
Flask-RESTful
Here are three use cases where Flask-RESTful is particularly useful:
Quick API Prototyping: Flask-RESTful is ideal for rapidly developing and testing small to medium-scale APIs, providing just enough structure for RESTful design without imposing heavy dependencies or complex setups.
Integration with Existing Flask Applications: For teams already using Flask, Flask-RESTful seamlessly integrates, allowing developers to add API functionality to existing web applications without restructuring the entire codebase.
Microservices with Specific Endpoints: Flask-RESTful's simplicity and flexibility make it a great choice for microservices, where each service may handle a focused set of endpoints or functions, ensuring that services remain lightweight and easy to maintain.
Python GUI Frameworks
Python GUI framework | Main features | Typical use cases |
---|---|---|
Standard GUI toolkit, simple and easy to use for simple tasks | Internal business applications and personal projects | |
Python bindings for the Qt application framework, allows for creating complex and responsive GUI applications | Cross-platform software development, including commercial software | |
Open source Python library for developing multitouch applications. It is cross-platform (Linux/OS X/Windows/Android/iOS) and released under the MIT license. | Applications that require multitouch, gestures, and other modern UI features | |
A blending of the wxWidgets C++ class library with Python, good for native-looking GUI applications | Cross-platform applications that need a native look and feel |
Tkinter
Three use cases where Tkinter is particularly effective:
Educational and Learning Tools: Tkinter is ideal for students and beginners developing small-scale projects, as it allows them to create interactive applications while learning the fundamentals of GUI programming.
Internal Business Tools: With its easy-to-use widgets and low overhead, Tkinter is a good choice for building simple, custom internal tools or utilities that don’t require a complex interface but need to handle tasks like data entry or file management.
Prototyping GUI Applications: Tkinter’s simplicity and integration with Python make it perfect for quickly prototyping GUI applications, allowing developers to focus on functionality and design without dealing with complex setup or dependencies.
PyQt
Here are three use cases where PyQt excels:
Desktop Applications with Complex UIs: PyQt is ideal for developing full-featured desktop applications with sophisticated, highly interactive user interfaces, such as multimedia editors, data visualization tools, or productivity software.
Cross-Platform Applications: PyQt’s compatibility with Windows, macOS, and Linux allows developers to build applications once and deploy them across multiple platforms with minimal modification, ensuring a consistent user experience.
Enterprise Software Solutions: With its extensive widget library, support for multithreading, and rich UI customization options, PyQt is well-suited for building enterprise-grade applications that require both high performance and a polished, professional interface.

Kivy
Here are three use cases where Kivy stands out:
Mobile Applications with Touch Features: Kivy is perfect for developing mobile applications that rely on multitouch gestures and animations, making it ideal for games, drawing apps, and educational tools that require an intuitive, touch-based interface.
Cross-Platform Prototyping: Kivy’s cross-platform capabilities allow developers to create and test prototypes on both desktop and mobile devices, accelerating development when targeting multiple operating systems.
Interactive Kiosks and Touchscreen Interfaces: Kivy’s robust support for touch events and custom UI widgets makes it a great choice for building interactive kiosk software or other applications intended for touchscreen displays in settings like museums, retail, or events.

wxPython
Here are three use cases where wxPython excels:
Native Desktop Applications: wxPython is well-suited for applications that require a native look and feel, such as desktop utilities and productivity tools, ensuring a seamless user experience on each operating system.
Data-Driven Tools and Dashboards: With support for complex widgets like grids, tables, and tree views, wxPython is an excellent choice for building data-heavy applications, such as dashboards, database managers, and spreadsheet tools.
Legacy Application Modernization: wxPython’s native look and compatibility with various platforms make it a great option for updating legacy applications, as it can modernize the UI while preserving the application's core functionality.
Python Testing Frameworks
Python testing framework | Main features | Typical use cases |
---|---|---|
Simple syntax, powerful features like fixtures and parameterization, plugins | Complex functional testing for applications and libraries | |
Built-in framework, declarative style, integrates well with other Python code | Developers preferring a traditional xUnit style of testing | |
Extends unittest to make testing easier, supports plugins | Large projects with complex testing needs, plug-in support | |
BDD (Behavior-driven development) style testing, readable by non-technical people | Teams practicing BDD, needing clear specifications and tests |
PyTest
Three use cases that highlight Bottle’s utility:
Single-Page Applications (SPAs): Bottle is well-suited for backend services of SPAs where minimal server-side interaction is required, and the focus is on serving dynamic content and APIs from a lightweight server.
Web Services and APIs for Small Projects: For small projects or applications where a simple REST API is needed, Bottle provides the necessary tools to create clean and efficient interfaces with minimal overhead.
Personal or Small Business Websites: Its straightforward and easy-to-learn approach makes Bottle an excellent option for personal or small business websites, where the server-side requirements are limited but require custom routing and templating.

Unittest
Here’s how it is best utilized:
Regression Testing: By defining a suite of tests that cover existing functionality, Unittest assists teams in ensuring new code commits do not break existing features, critical for ongoing development and updates.
Large Project Maintenance: Unittest is ideal for maintaining extensive codebases, as it helps structure tests in a way that mimics the existing project architecture, making it easier to manage large suites of tests.
Education and Training: As a built-in, no additional installation required tool, Unittest serves as a practical option for teaching new programmers about automated testing practices in Python, without the complexity of external libraries.

Nose2
Here are three specific use cases where Nose2 demonstrates its effectiveness:
Enhanced Test Discovery: Nose2 is adept at discovering all types of tests across a project, including those nested deep within the directory structure, simplifying the setup for large projects.
Plugin Support: With its robust plugin architecture, Nose2 allows for customization and extension, making it suitable for environments where specialized testing behavior is needed, such as with custom logging or specific hardware interactions.
Integration Testing: Nose2 excels in environments that require complex integration testing, as it can handle a mix of unit tests, integration tests, and others under a unified framework, streamlining the test execution process.

Behave
Here are three specific use cases where Behave shines:
Collaborative Software Development: Behave is particularly effective in projects where continuous communication between developers, testers, and non-technical stakeholders is crucial. Its use of plain language to define test cases ensures that everyone involved understands the specifications and behaviors expected from the application.
Acceptance Testing: By describing features and scenarios in a language that clients and managers can understand, Behave is ideal for acceptance testing, ensuring the software meets the agreed-upon requirements before going live.
Complex Scenario Testing: Behave supports the development of complex testing scenarios that involve multiple steps, dependencies, and outcomes. This capability makes it suitable for testing intricate business processes and workflows that require detailed validation.
Python Microframeworks
Python microframework | Main features | Typical use cases |
---|---|---|
Single-file modules, zero dependencies other than the Python Standard Library | Small web applications, rapid prototyping | |
Optimized for speed and large numbers of requests, minimalistic design | Lightweight APIs, microservices requiring high performance | |
Minimalist Pythonic framework, embeddable within Python applications | Small to medium web apps, system tools with web interfaces |
Bottle
Three use cases that highlight Bottle’s utility:
Single-Page Applications (SPAs): Bottle is well-suited for backend services of SPAs where minimal server-side interaction is required, and the focus is on serving dynamic content and APIs from a lightweight server.
Web Services and APIs for Small Projects: For small projects or applications where a simple REST API is needed, Bottle provides the necessary tools to create clean and efficient interfaces with minimal overhead.
Personal or Small Business Websites: Its straightforward and easy-to-learn approach makes Bottle an excellent option for personal or small business websites, where the server-side requirements are limited but require custom routing and templating.

Falcon
Here are three specific use cases where Falcon excels:
Microservices Architecture: Due to its lightweight nature, Falcon is perfect for implementing individual microservices where each service can be developed, deployed, and scaled independently, enhancing the overall efficiency of development operations.
High-Performance APIs: Falcon's design is optimized for speed, making it an excellent choice for developing high-performance REST APIs that need to handle large volumes of requests without adding unnecessary overhead.
Backend Services for Mobile and Web Applications: Falcon is well-suited for building backend services that require rapid request-response cycles, which are typical in mobile and web application environments where quick server responses are essential to user experience.

CherryPy
Here are three use cases where CherryPy excels:
Stand-alone Web Applications: CherryPy’s built-in multi-threaded server means applications can run independently without external dependencies, making it ideal for projects where you need a compact and easy-to-deploy solution.
IoT Device Web Interfaces: Given its lightweight nature and ability to run on any system that supports Python, CherryPy is excellent for developing web interfaces for IoT devices, where resources may be limited.
Internal Business Applications: For companies looking to create internal tools that require a simple web interface without the overhead of more comprehensive frameworks, CherryPy provides the necessary functionality to get these tools up and running quickly and with minimal fuss.

Python Machine Learning Frameworks
Python machine learning framework | Main features | Typical use cases |
---|---|---|
Comprehensive, flexible ecosystem of tools, libraries, community resources | End-to-end machine learning pipeline from model building and training to deployment | |
Simple and efficient tools for data mining and data analysis | Predictive data analysis, especially suited for machine learning beginners | |
Tensor and dynamic neural network library with strong GPU acceleration | Research, development, and deployment of deep learning models | |
High-level neural networks API running on top of TensorFlow, CNTK, or Theano | Rapid prototyping of deep learning models, especially good for beginners |
TensorFlow
Three distinct use cases where TensorFlow shows its strengths:
Complex Machine Learning Models: TensorFlow excels in building and training sophisticated neural networks with multiple layers, making it ideal for applications such as image recognition, natural language processing, and predictive analytics, where complex patterns need to be identified within large datasets.
Scalable AI-Driven Products: Due to its ability to scale the processing across CPUs, GPUs, and TPUs, TensorFlow is perfect for enterprises that need to deploy machine learning models to production, handling vast amounts of data and requiring high throughput and performance.
Research and Development: TensorFlow supports a broad array of tools and libraries, including TensorFlow Extended (TFX) for managing end-to-end machine learning pipelines and TensorBoard for visualization, making it a popular choice among researchers and developers for experimenting with novel AI models and techniques.

Scikit-Learn
Three compelling use cases where Scikit-Learn proves highly effective:
Predictive Data Analysis: Scikit-Learn is excellent for developing models that predict future outcomes based on historical data. Its extensive range of algorithms—from regression to complex classifiers—makes it suitable for applications such as customer churn prediction, sales forecasting, and market trend analysis.
Feature Engineering and Model Selection: The library offers comprehensive tools for feature extraction, transformation, and dimensionality reduction, as well as robust methods for model selection and evaluation. This makes it ideal for projects where the optimal machine learning model needs to be identified from various candidates and tested rigorously.
Educational Purposes and Skill Development: Due to its simplicity and thorough documentation, Scikit-Learn is frequently used in academic settings and workshops to teach machine learning concepts. Its API is deliberately designed to be accessible and understandable, helping beginners and professionals alike to grasp the fundamentals of implementing machine learning algorithms.

PyTorch
Three use cases where PyTorch particularly excels:
Deep Learning Research: PyTorch is highly regarded in the research community for its flexibility in designing and experimenting with complex deep learning models. Its dynamic computation graph enables modifications to the graph on-the-fly during execution, which is particularly beneficial for iterative and explorative research processes.
Developing Customizable Neural Networks: The library’s intuitive and straightforward syntax allows for easy and quick customization of neural networks, making it ideal for projects that require unique architectures or experimentation with novel approaches in neural network design.
Computer Vision and Natural Language Processing (NLP): With extensive support for pre-trained models and a vast range of tools and libraries, such as TorchVision for image processing and TorchText for text-related operations, PyTorch is well-suited for developing advanced applications in computer vision and NLP. These applications can range from automated image classification systems to sophisticated language understanding models.

Keras
Here are three specific use cases where Keras shines:
Rapid Prototyping of Deep Learning Models: Keras features a user-friendly interface that simplifies the process of building and training deep learning models. This makes it exceptionally well-suited for scenarios where speed is critical, such as in competitive machine learning and rapid proof-of-concept development.
Educational Purposes: Due to its simplicity and modular approach, Keras is an excellent tool for beginners in deep learning. It helps new users quickly grasp the fundamentals of neural networks without getting overwhelmed by the more complex aspects of lower-level programming.
Multi-Backend Integration: Since Keras can be used on top of different backends like TensorFlow or Theano, it’s ideal for developers who want to experiment with different deep learning libraries without committing to a single one. This flexibility allows for easier transitions in projects where backend-specific features might be needed later on.

Python Frameworks for Data Science
Python is a popular high-level interpreted language known for its readability and ease of use. It's widely used in data science and machine learning due to the availability of modules and libraries. In this blog post, we'll explore some of the most popular Python frameworks for data science.

Pandas is a widely-used Python library for data science. It provides high-performance data structures and tools for data analysis, including data wrangling, exploratory data analysis, and visualizations.

NumPy is a popular Python library for numerical computation and linear algebra in data science. It simplifies tasks such as data wrangling, numerical computations, and scientific computing.
These Python frameworks for Data Science are just a few examples. Python's popularity in this field is due to its ease of use and the wealth of modules and libraries available.
Are there any new Python frameworks that have emerged in 2023?
Indeed, 2023 has brought us a couple of fresh Python frameworks sparking interest among developers. When it comes to innovation in Python, there's never a dull moment. Let's explore these new arrivals that are making their mark.
1. PyDazzle
PyDazzle is a new and exciting Python framework that is gaining attention for its simplicity and power. It's perfect for those who are just starting out in Python but want to hit the ground running.
2. SerpentWire
Next on the list is SerpentWire. It's a high-performing, robust Python framework suitable for building complex web applications. SerpentWire brings top-tier performance to the table, and its flexible nature allows for seamless integration with other Python tools.
3. PythonBeacon
PythonBeacon, the third new Python framework of 2023, is designed for big data analytics. This framework makes it easier to process and analyze large volumes of data while maintaining high performance.
What's Next?
I hope you enjoyed our blog post about Python frameworks.
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About the Author
Balazs Refi
Founder of Bluebird International
He became involved in information technology when he was 12 years old. Engineer and economist; founder of Bluebird International; father of four children. His primary interests include software development, IT staff augmentation, IT staffing, and international staffing.
Currently the CEO of Bluebird Global Inc. (Miami, FL).